2021 Conference USA Leaders Total Defense - Games vs. FBS Teams With Winning Record Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Charlotte | 4 | 802 | 1178 | 263 | 1980 | 7.53 | 495.0 |
| 2 | UTEP | 4 | 798 | 1020 | 276 | 1818 | 6.59 | 454.5 |
| 3 | Southern Mississippi | 5 | 987 | 1057 | 289 | 2044 | 7.07 | 408.8 |
| 4 | UAB | 6 | 764 | 1661 | 372 | 2425 | 6.52 | 404.2 |
| 5 | Middle Tennessee | 5 | 880 | 1313 | 387 | 2193 | 5.67 | 438.6 |
| 6 | Rice | 6 | 992 | 1699 | 388 | 2691 | 6.94 | 448.5 |
| 7 | Florida International | 5 | 1034 | 1549 | 392 | 2583 | 6.59 | 516.6 |
| 8 | Louisiana Tech | 6 | 1025 | 1674 | 411 | 2699 | 6.57 | 449.8 |
| 9 | UTSA | 6 | 649 | 2125 | 419 | 2774 | 6.62 | 462.3 |
| 10 | Florida Atlantic | 6 | 1007 | 1609 | 424 | 2616 | 6.17 | 436.0 |
| 11 | North Texas | 7 | 1109 | 1837 | 468 | 2946 | 6.29 | 420.9 |
| 12 | Marshall | 6 | 1123 | 1639 | 484 | 2762 | 5.71 | 460.3 |
| 13 | Western Kentucky | 7 | 1537 | 1811 | 544 | 3348 | 6.15 | 478.3 |
| 14 | Old Dominion | 7 | 1045 | 1915 | 548 | 2960 | 5.40 | 422.9 |