2021 Conference USA Leaders Total Defense - Games in August/September Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | UTSA | 4 | 325 | 819 | 239 | 1144 | 4.79 | 286.0 |
| 2 | Western Kentucky | 3 | 674 | 645 | 242 | 1319 | 5.45 | 439.7 |
| 3 | Southern Mississippi | 4 | 353 | 1009 | 246 | 1362 | 5.54 | 340.5 |
| 4 | UTEP | 4 | 453 | 812 | 251 | 1265 | 5.04 | 316.3 |
| 5 | Old Dominion | 4 | 556 | 708 | 260 | 1264 | 4.86 | 316.0 |
| 5 | Charlotte | 4 | 922 | 796 | 260 | 1718 | 6.61 | 429.5 |
| 7 | Rice | 4 | 910 | 927 | 265 | 1837 | 6.93 | 459.3 |
| 8 | UAB | 4 | 444 | 866 | 266 | 1310 | 4.92 | 327.5 |
| 9 | North Texas | 4 | 691 | 956 | 272 | 1647 | 6.06 | 411.8 |
| 10 | Florida Atlantic | 4 | 1014 | 549 | 279 | 1563 | 5.60 | 390.8 |
| 11 | Florida International | 4 | 646 | 1164 | 305 | 1810 | 5.93 | 452.5 |
| 12 | Middle Tennessee | 4 | 694 | 961 | 312 | 1655 | 5.30 | 413.8 |
| 13 | Louisiana Tech | 4 | 592 | 1352 | 326 | 1944 | 5.96 | 486.0 |
| 14 | Marshall | 4 | 857 | 845 | 336 | 1702 | 5.07 | 425.5 |