2021 Conference USA Leaders Rushing Defense - From Opponent's 21 To 39 Yard Line through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Long | 1st | 10+ | 20+ | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Rice | 12 | 100 | 577 | 5.77 | 3 | 72 | 31 | 19 | 6 |
| 2 | Louisiana Tech | 12 | 122 | 590 | 4.84 | 1 | 70 | 30 | 20 | 4 |
| 3 | Florida Atlantic | 12 | 126 | 632 | 5.02 | 1 | 73 | 29 | 15 | 8 |
| 3 | Florida International | 12 | 126 | 739 | 5.87 | 1 | 61 | 33 | 20 | 7 |
| 5 | Old Dominion | 13 | 132 | 576 | 4.36 | 0 | 56 | 33 | 13 | 3 |
| 6 | Charlotte | 12 | 134 | 832 | 6.21 | 0 | 64 | 37 | 22 | 9 |
| 7 | UTEP | 13 | 135 | 674 | 4.99 | 1 | 75 | 31 | 17 | 7 |
| 8 | Southern Mississippi | 12 | 137 | 584 | 4.26 | 0 | 44 | 28 | 19 | 9 |
| 9 | UAB | 13 | 138 | 546 | 3.96 | 1 | 62 | 26 | 17 | 5 |
| 10 | Middle Tennessee | 13 | 154 | 603 | 3.92 | 0 | 30 | 33 | 17 | 6 |
| 11 | North Texas | 13 | 157 | 658 | 4.19 | 1 | 69 | 30 | 18 | 5 |
| 12 | Western Kentucky | 14 | 169 | 903 | 5.34 | 1 | 65 | 51 | 30 | 6 |
| 13 | UTSA | 14 | 171 | 609 | 3.56 | 0 | 34 | 34 | 20 | 4 |
| 14 | Marshall | 13 | 184 | 941 | 5.11 | 1 | 75 | 51 | 27 | 11 |
| 1st: First Downs; 10+: Rush attempts of 10 or more yards; 20+: Rush attempts of 20 or more yards | ||||||||||