2021 Conference USA Leaders Rushing Defense - From Own 39 To 21 Yard Line through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Long | 1st | 10+ | 20+ | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Florida Atlantic | 12 | 62 | 270 | 4.35 | 3 | 24 | 16 | 8 | 4 |
| 2 | North Texas | 13 | 67 | 179 | 2.67 | 1 | 36 | 14 | 6 | 2 |
| 3 | Old Dominion | 12 | 68 | 239 | 3.51 | 0 | 25 | 17 | 6 | 2 |
| 3 | Rice | 12 | 68 | 414 | 6.09 | 3 | 34 | 27 | 16 | 4 |
| 5 | Southern Mississippi | 12 | 73 | 381 | 5.22 | 2 | 38 | 21 | 11 | 4 |
| 6 | Middle Tennessee | 13 | 75 | 338 | 4.51 | 1 | 33 | 22 | 13 | 5 |
| 7 | UTSA | 14 | 77 | 276 | 3.58 | 0 | 18 | 19 | 6 | 0 |
| 8 | UTEP | 12 | 80 | 294 | 3.68 | 1 | 27 | 21 | 10 | 1 |
| 9 | UAB | 12 | 81 | 368 | 4.54 | 0 | 24 | 26 | 15 | 4 |
| 10 | Louisiana Tech | 12 | 82 | 431 | 5.26 | 4 | 38 | 29 | 14 | 5 |
| 11 | Florida International | 12 | 84 | 479 | 5.70 | 4 | 32 | 31 | 21 | 4 |
| 12 | Charlotte | 12 | 89 | 454 | 5.10 | 5 | 31 | 25 | 16 | 6 |
| 13 | Western Kentucky | 14 | 99 | 433 | 4.37 | 3 | 25 | 29 | 15 | 6 |
| 14 | Marshall | 13 | 108 | 276 | 2.56 | 0 | 22 | 24 | 7 | 1 |
| 1st: First Downs; 10+: Rush attempts of 10 or more yards; 20+: Rush attempts of 20 or more yards | ||||||||||