2021 Conference USA Leaders All Purpose - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | Team | Yr | Pos | G | Rush | Recv. | Punt Ret. | Kick Ret. | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Roger Cray | ODU | SR | CB | 1 | 0 | 0 | 41 | 0 | 3 | 41 | 13.7 | 41.0 |
| 2 | Willie Johnson | Marshall | SR | WR | 1 | 21 | 0 | 36 | 0 | 5 | 57 | 11.4 | 57.0 |
| 3 | Da'quan Bailey-Brown | USM | JR | WR | 1 | 0 | 3 | 18 | 0 | 3 | 21 | 7.0 | 21.0 |
| 4 | Sean Fresch | Rice | FR | CB | 2 | 0 | 0 | 16 | 39 | 4 | 55 | 13.8 | 27.5 |
| 5 | Cade Stoever | UTSA | JR | WR | 1 | 0 | 0 | 12 | 0 | 2 | 12 | 6.0 | 12.0 |
| 6 | Smoke Harris | La Tech | SO | WR | 1 | 0 | 39 | 11 | 0 | 8 | 50 | 6.3 | 50.0 |
| 7 | Kenneth Orji | Rice | JR | RSH | 2 | 0 | 0 | 3 | 0 | 1 | 3 | 3.0 | 1.5 |
| 8 | Jerreth Sterns | Western Ky | JR | WR | 1 | 0 | 186 | 2 | 0 | 18 | 188 | 10.4 | 188.0 |
| 8 | Starling Thomas V | UAB | JR | CB | 2 | 0 | 0 | 2 | 0 | 2 | 2 | 1.0 | 1.0 |