2021 Conference USA Leaders All Purpose - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | Team | Yr | Pos | G | Rush | Recv. | Punt Ret. | Kick Ret. | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Roger Cray | ODU | SR | CB | 1 | 0 | 0 | 41 | 0 | 3 | 41 | 13.7 | 41.0 |
| 2 | Smoke Harris | La Tech | SO | WR | 2 | 0 | 91 | 35 | 0 | 15 | 126 | 8.4 | 63.0 |
| 3 | Da'quan Bailey-Brown | USM | JR | WR | 1 | 0 | 3 | 18 | 0 | 3 | 21 | 7.0 | 21.0 |
| 4 | Sean Fresch | Rice | FR | CB | 2 | 0 | 0 | 16 | 68 | 5 | 84 | 16.8 | 42.0 |
| 4 | Sheldon Jones | UTSA | SR | WR | 1 | 0 | 0 | 16 | 0 | 2 | 16 | 8.0 | 16.0 |
| 6 | Kenneth Orji | Rice | JR | RSH | 2 | 0 | 0 | 3 | 0 | 1 | 3 | 3.0 | 1.5 |
| 7 | Jerreth Sterns | Western Ky | JR | WR | 2 | 7 | 268 | 2 | 0 | 27 | 277 | 10.3 | 138.5 |