2021 Conference USA Leaders All Purpose - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | Team | Yr | Pos | G | Rush | Recv. | Punt Ret. | Kick Ret. | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Mitchell Tinsley | Western Ky | JR | WR | 1 | 0 | 127 | 0 | 0 | 7 | 127 | 18.1 | 127.0 |
| 2 | Bub Means | La Tech | FR | WR | 1 | 0 | 95 | 0 | 21 | 7 | 116 | 16.6 | 116.0 |
| 3 | Willie Johnson | Marshall | SR | WR | 1 | 21 | 0 | 36 | 0 | 5 | 57 | 11.4 | 57.0 |
| 4 | Stone Smartt | ODU | SR | QB | 1 | 1 | 26 | 0 | 52 | 7 | 79 | 11.3 | 79.0 |
| 5 | Zakhari Franklin | UTSA | JR | WR | 1 | 0 | 89 | 0 | 0 | 8 | 89 | 11.1 | 89.0 |
| 6 | De'Corian Clark | UTSA | JR | WR | 1 | 2 | 72 | 0 | 0 | 7 | 74 | 10.6 | 74.0 |
| 7 | Jerreth Sterns | Western Ky | JR | WR | 1 | 0 | 186 | 2 | 0 | 18 | 188 | 10.4 | 188.0 |
| 8 | Malachi Corley | Western Ky | FR | WR | 1 | 0 | 69 | 0 | 0 | 7 | 69 | 9.9 | 69.0 |
| 9 | Rasheen Ali | Marshall | FR | RB | 1 | 160 | 5 | 0 | 0 | 21 | 165 | 7.9 | 165.0 |
| 10 | Smoke Harris | La Tech | SO | WR | 1 | 0 | 39 | 11 | 0 | 8 | 50 | 6.3 | 50.0 |
| 11 | DeWayne McBride | UAB | SO | RB | 2 | 244 | 0 | 0 | 0 | 41 | 244 | 6.0 | 122.0 |
| 11 | Chandler Pittman | USM | FR | RB | 1 | 28 | 14 | 0 | 0 | 7 | 42 | 6.0 | 42.0 |
| 13 | Jermaine Brown Jr. | UAB | JR | RB | 2 | 76 | 19 | 0 | 15 | 19 | 110 | 5.8 | 55.0 |
| 14 | Corey Gammage | Marshall | SO | WR | 1 | 0 | 50 | 0 | 0 | 9 | 50 | 5.6 | 50.0 |
| 15 | Elijah Davis | ODU | SO | RB | 1 | 69 | 3 | 0 | 0 | 13 | 72 | 5.5 | 72.0 |
| 16 | Noah Whittington | Western Ky | FR | RB | 1 | 37 | 6 | 0 | 0 | 8 | 43 | 5.4 | 43.0 |
| 17 | Adam Cofield | Western Ky | SR | RB | 1 | 15 | 33 | 0 | 0 | 9 | 48 | 5.3 | 48.0 |
| 18 | Dajon Richard | USM | FR | RB | 1 | 7 | 19 | 0 | 0 | 5 | 26 | 5.2 | 26.0 |
| 19 | Jordan Myers | Rice | SR | TE | 2 | 23 | 52 | 0 | 16 | 18 | 91 | 5.1 | 45.5 |
| 20 | Brenden Brady | UTSA | SR | RB | 1 | 76 | 8 | 0 | 0 | 17 | 84 | 4.9 | 84.0 |
| 21 | Austin Kendall | La Tech | SR | QB | 1 | 71 | 0 | 0 | 0 | 15 | 71 | 4.7 | 71.0 |
| 22 | Ari Broussard | Rice | SO | RB | 2 | 56 | 0 | 0 | 0 | 14 | 56 | 4.0 | 28.0 |
| 23 | Khalan Griffin | Rice | FR | RB | 2 | 121 | 0 | 0 | 0 | 32 | 121 | 3.8 | 60.5 |
| 24 | Blake Watson | ODU | SO | RB | 1 | 55 | 1 | 0 | 0 | 16 | 56 | 3.5 | 56.0 |
| 25 | Marcus Williams Jr. | La Tech | SR | RB | 1 | 59 | -1 | 0 | 0 | 17 | 58 | 3.4 | 58.0 |
| 25 | Ty Keyes | USM | FR | QB | 1 | 41 | 0 | 0 | 0 | 12 | 41 | 3.4 | 41.0 |
| 27 | Kye Robichaux | Western Ky | FR | RB | 1 | 18 | 0 | 0 | 0 | 6 | 18 | 3.0 | 18.0 |
| 28 | D.J. Mack Jr. | ODU | JR | QB | 1 | 13 | 0 | 0 | 0 | 8 | 13 | 1.6 | 13.0 |
| 29 | Frank Gore, Jr. | USM | FR | RB | 1 | 7 | 4 | 0 | 0 | 10 | 11 | 1.1 | 11.0 |
| 30 | Luke McCaffrey | Rice | FR | QB | 2 | 11 | 0 | 0 | 0 | 12 | 11 | 0.9 | 5.5 |
| 31 | Dylan Hopkins | UAB | JR | QB | 2 | -10 | 0 | 0 | 0 | 12 | -10 | -0.8 | -5.0 |
| 32 | Bailey Zappe | Western Ky | SR | QB | 1 | -17 | 0 | 0 | 0 | 7 | -17 | -2.4 | -17.0 |
Note: To qualify, player must have played in 75% of his team's games and have a minimum of 5.0 plays per game played.