2016 Atlantic Coast Conference Leaders Total Defense - Games vs. Ranked Teams Only (AP Poll) through 01/09/2017
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Virginia Tech | 2 | 362 | 566 | 130 | 928 | 7.14 | 464.0 |
| 2 | Duke | 3 | 719 | 610 | 198 | 1329 | 6.71 | 443.0 |
| 3 | Louisville | 3 | 549 | 636 | 199 | 1185 | 5.95 | 395.0 |
| 4 | North Carolina | 4 | 822 | 741 | 292 | 1563 | 5.35 | 390.8 |
| 5 | Virginia | 3 | 645 | 788 | 226 | 1433 | 6.34 | 477.7 |
| 6 | Georgia Tech | 3 | 474 | 812 | 224 | 1286 | 5.74 | 428.7 |
| 7 | Miami (Florida) | 4 | 641 | 933 | 289 | 1574 | 5.45 | 393.5 |
| 8 | Wake Forest | 4 | 703 | 1062 | 285 | 1765 | 6.19 | 441.3 |
| 9 | Florida State | 5 | 884 | 1066 | 340 | 1950 | 5.74 | 390.0 |
| 10 | Boston College | 4 | 843 | 1072 | 273 | 1915 | 7.01 | 478.8 |
| 11 | North Carolina State | 3 | 343 | 1098 | 234 | 1441 | 6.16 | 480.3 |
| 12 | Clemson | 7 | 1090 | 1630 | 497 | 2720 | 5.47 | 388.6 |
| 13 | Pittsburgh | 4 | 374 | 1858 | 321 | 2232 | 6.95 | 558.0 |
| 14 | Syracuse | 6 | 1731 | 1899 | 436 | 3630 | 8.33 | 605.0 |