2016 Conference USA Leaders Total Offense - Games vs. FBS Power 5 Conference Teams Only through 01/09/2017
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Middle Tennessee | 2 | 407 | 683 | 168 | 1090 | 6.49 | 545.0 |
| 2 | Louisiana Tech | 2 | 340 | 523 | 122 | 863 | 7.07 | 431.5 |
| 3 | Southern Mississippi | 2 | 343 | 419 | 169 | 762 | 4.51 | 381.0 |
| 4 | Western Kentucky | 2 | 228 | 507 | 133 | 735 | 5.53 | 367.5 |
| 5 | Florida International | 2 | 265 | 438 | 136 | 703 | 5.17 | 351.5 |
| 6 | UTSA | 2 | 141 | 433 | 135 | 574 | 4.25 | 287.0 |
| 7 | Rice | 2 | 401 | 155 | 156 | 556 | 3.56 | 278.0 |
| 8 | Marshall | 2 | 252 | 299 | 126 | 551 | 4.37 | 275.5 |
| 9 | Florida Atlantic | 2 | 129 | 296 | 136 | 425 | 3.13 | 212.5 |
| 10 | Old Dominion | 1 | 117 | 204 | 59 | 321 | 5.44 | 321.0 |
| 11 | UTEP | 1 | 135 | 73 | 61 | 208 | 3.41 | 208.0 |
| 11 | Charlotte | 1 | 48 | 160 | 63 | 208 | 3.30 | 208.0 |
| 13 | North Texas | 1 | -13 | 66 | 50 | 53 | 1.06 | 53.0 |