2021 Conference USA Leaders Total Offense - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Western Kentucky | 2 | 165 | 853 | 155 | 1018 | 6.57 | 509.0 |
| 2 | Louisiana Tech | 2 | 240 | 609 | 141 | 849 | 6.02 | 424.5 |
| 3 | Charlotte | 2 | 232 | 515 | 119 | 747 | 6.28 | 373.5 |
| 4 | Rice | 2 | 225 | 355 | 130 | 580 | 4.46 | 290.0 |
| 5 | UTSA | 1 | 217 | 280 | 82 | 497 | 6.06 | 497.0 |
| 6 | North Texas | 1 | 188 | 305 | 75 | 493 | 6.57 | 493.0 |
| 7 | Florida Atlantic | 1 | 92 | 261 | 70 | 353 | 5.04 | 353.0 |
| 8 | Middle Tennessee | 1 | 66 | 283 | 76 | 349 | 4.59 | 349.0 |
| 9 | Old Dominion | 1 | 145 | 127 | 77 | 272 | 3.53 | 272.0 |
| 10 | Florida International | 1 | 55 | 191 | 58 | 246 | 4.24 | 246.0 |
| 11 | Southern Mississippi | 1 | 82 | 131 | 57 | 213 | 3.74 | 213.0 |
| 12 | UAB | 1 | 127 | 47 | 53 | 174 | 3.28 | 174.0 |