2021 American Athletic Conference Leaders Total Offense - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | East Carolina | 10 | 1679 | 2863 | 777 | 4542 | 5.85 | 454.2 |
| 2 | SMU | 10 | 1416 | 3090 | 737 | 4506 | 6.11 | 450.6 |
| 3 | Tulsa | 10 | 2053 | 2390 | 750 | 4443 | 5.92 | 444.3 |
| 4 | Cincinnati | 11 | 2095 | 2762 | 676 | 4857 | 7.18 | 441.5 |
| 5 | Memphis | 10 | 1236 | 3161 | 723 | 4397 | 6.08 | 439.7 |
| 6 | Houston | 11 | 1636 | 3087 | 759 | 4723 | 6.22 | 429.4 |
| 7 | Tulane | 9 | 1444 | 1909 | 607 | 3353 | 5.52 | 372.6 |
| 8 | UCF | 10 | 1762 | 1947 | 641 | 3709 | 5.79 | 370.9 |
| 9 | South Florida | 9 | 1444 | 1791 | 633 | 3235 | 5.11 | 359.4 |
| 10 | Navy | 12 | 2717 | 681 | 794 | 3398 | 4.28 | 283.2 |
| 11 | Temple | 9 | 1009 | 1525 | 539 | 2534 | 4.70 | 281.6 |