2021 American Athletic Conference Leaders Total Offense - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Tulsa | 4 | 524 | 1070 | 299 | 1594 | 5.33 | 398.5 |
| 2 | South Florida | 4 | 489 | 887 | 278 | 1376 | 4.95 | 344.0 |
| 3 | Cincinnati | 3 | 377 | 631 | 165 | 1008 | 6.11 | 336.0 |
| 3 | Houston | 1 | 86 | 250 | 73 | 336 | 4.60 | 336.0 |
| 5 | Tulane | 4 | 520 | 769 | 265 | 1289 | 4.86 | 322.3 |
| 6 | Memphis | 1 | 106 | 216 | 74 | 322 | 4.35 | 322.0 |
| 7 | East Carolina | 2 | 136 | 506 | 149 | 642 | 4.31 | 321.0 |
| 8 | UCF | 1 | 155 | 141 | 64 | 296 | 4.63 | 296.0 |
| 9 | SMU | 2 | 183 | 371 | 118 | 554 | 4.69 | 277.0 |
| 10 | Navy | 3 | 560 | 232 | 205 | 792 | 3.86 | 264.0 |
| 11 | Temple | 2 | 183 | 269 | 109 | 452 | 4.15 | 226.0 |