2021 American Athletic Conference Leaders Total Offense - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | SMU | 10 | 1754 | 3283 | 772 | 5037 | 6.52 | 503.7 |
| 2 | Tulsa | 9 | 1972 | 2174 | 661 | 4146 | 6.27 | 460.7 |
| 3 | East Carolina | 10 | 1809 | 2747 | 750 | 4556 | 6.07 | 455.6 |
| 4 | Memphis | 11 | 1539 | 3369 | 787 | 4908 | 6.24 | 446.2 |
| 5 | Cincinnati | 11 | 2040 | 2746 | 698 | 4786 | 6.86 | 435.1 |
| 6 | Houston | 13 | 1906 | 3552 | 900 | 5458 | 6.06 | 419.8 |
| 7 | Tulane | 8 | 1457 | 1892 | 558 | 3349 | 6.00 | 418.6 |
| 8 | UCF | 12 | 2397 | 2539 | 802 | 4936 | 6.15 | 411.3 |
| 9 | South Florida | 8 | 1413 | 1422 | 563 | 2835 | 5.04 | 354.4 |
| 10 | Temple | 10 | 1132 | 1857 | 615 | 2989 | 4.86 | 298.9 |
| 11 | Navy | 9 | 2157 | 449 | 589 | 2606 | 4.42 | 289.6 |