2025 American Conference Leaders Total Defense - Games vs. FBS Power 5 Conference Teams Only through 10/09/2025
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | North Texas | 1 | 64 | 211 | 63 | 275 | 4.37 | 275.0 |
| 2 | Army | 1 | 74 | 172 | 43 | 246 | 5.72 | 246.0 |
| 3 | UTSA | 1 | 108 | 291 | 59 | 399 | 6.76 | 399.0 |
| 4 | Florida Atlantic | 1 | 112 | 268 | 77 | 380 | 4.94 | 380.0 |
| 5 | Charlotte | 1 | 148 | 155 | 58 | 303 | 5.22 | 303.0 |
| 6 | Memphis | 1 | 175 | 325 | 66 | 500 | 7.58 | 500.0 |
| 7 | Tulsa | 1 | 185 | 218 | 75 | 403 | 5.37 | 403.0 |
| 8 | Rice | 1 | 204 | 188 | 60 | 392 | 6.53 | 392.0 |
| 9 | UAB | 1 | 235 | 275 | 73 | 510 | 6.99 | 510.0 |
| 10 | East Carolina | 2 | 277 | 564 | 130 | 841 | 6.47 | 420.5 |
| 11 | USF | 2 | 338 | 593 | 132 | 931 | 7.05 | 465.5 |
| 12 | Tulane | 3 | 456 | 781 | 207 | 1237 | 5.98 | 412.3 |
| 13 | Temple | 2 | 535 | 448 | 127 | 983 | 7.74 | 491.5 |