2025 American Conference Leaders Sacks - Games vs. FBS Power 5 Conference Teams Only through 09/13/2025
| Name | Team | Yr | Pos | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Keviyan Huddleston | N Texas | SO | DL | 1 | 2.0 | 13 | 2.00 |
| 2 | Mac Harris | S Florida | SR | OLB | 2 | 2.0 | 5 | 1.00 |
| 2 | Charles Calhoun | Temple | SR | OLB | 1 | 1.0 | 10 | 1.00 |
| 2 | Sekou Kromah | Temple | SR | DT | 1 | 1.0 | 7 | 1.00 |
| 2 | Xavier McIver | ECU | SR | DL | 1 | 1.0 | 4 | 1.00 |
| 2 | Joshua Pierce | N Texas | SO | DL | 1 | 1.0 | 3 | 1.00 |
| 2 | Ty Morris | Rice | JR | LB | 1 | 1.0 | 3 | 1.00 |
| 2 | Michael Daley | Rice | JR | DE | 1 | 1.0 | 1 | 1.00 |
| 9 | Santana Hopper | Tulane | JR | DL | 2 | 1.0 | 12 | 0.50 |
| 9 | Jack Tchienchou | Tulane | SO | S | 2 | 1.0 | 11 | 0.50 |
| 9 | Harvey Dyson | Tulane | JR | BAN | 2 | 1.0 | 7 | 0.50 |
| 9 | Joseph Mutombo | Rice | SO | DL | 1 | 0.5 | 1 | 0.50 |
| 9 | Blake Boenisch | Rice | SR | DL | 1 | 0.5 | 1 | 0.50 |
Note: To qualify, player must have played in 75% of his team's games.