2025 American Conference Leaders Sacks - Games vs. FBS Power 5 Conference Teams Only through 09/12/2025
| Name | Team | Yr | Pos | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Santana Hopper | Tulane | JR | DL | 1 | 1.0 | 12 | 1.00 |
| 1 | Jack Tchienchou | Tulane | SO | S | 1 | 1.0 | 11 | 1.00 |
| 1 | Harvey Dyson | Tulane | JR | BAN | 1 | 1.0 | 7 | 1.00 |
| 1 | Xavier McIver | ECU | SR | DL | 1 | 1.0 | 4 | 1.00 |
| 1 | Ty Morris | Rice | JR | LB | 1 | 1.0 | 3 | 1.00 |
| 1 | Michael Daley | Rice | JR | DE | 1 | 1.0 | 1 | 1.00 |
| 1 | Mac Harris | S Florida | SR | OLB | 1 | 1.0 | 1 | 1.00 |
| 8 | Joseph Mutombo | Rice | SO | DL | 1 | 0.5 | 1 | 0.50 |
| 8 | Blake Boenisch | Rice | SR | DL | 1 | 0.5 | 1 | 0.50 |