2025 Big 12 Conference Leaders Rushing Defense - Games vs. FBS non-Power 5 Conference Teams Only through 11/04/2025
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Arizona | 1 | 29 | 67 | 2.31 | 0 | 29.00 | 67.00 |
| 1 | Colorado | 2 | 71 | 249 | 3.51 | 0 | 35.50 | 124.50 |
| 1 | Oklahoma State | 1 | 43 | 205 | 4.77 | 0 | 43.00 | 205.00 |
| 4 | Kansas | 1 | 29 | 37 | 1.28 | 1 | 29.00 | 37.00 |
| 4 | Texas Tech | 1 | 34 | 63 | 1.85 | 1 | 34.00 | 63.00 |
| 4 | Cincinnati | 1 | 34 | 98 | 2.88 | 1 | 34.00 | 98.00 |
| 4 | Arizona State | 1 | 42 | 119 | 2.83 | 1 | 42.00 | 119.00 |
| 4 | BYU | 1 | 35 | 119 | 3.40 | 1 | 35.00 | 119.00 |
| 4 | Utah | 1 | 34 | 121 | 3.56 | 1 | 34.00 | 121.00 |
| 4 | Iowa State | 1 | 40 | 160 | 4.00 | 1 | 40.00 | 160.00 |
| 4 | UCF | 1 | 39 | 165 | 4.23 | 1 | 39.00 | 165.00 |
| 4 | Houston | 1 | 53 | 177 | 3.34 | 1 | 53.00 | 177.00 |
| 4 | West Virginia | 1 | 48 | 182 | 3.79 | 1 | 48.00 | 182.00 |
| 14 | Kansas State | 1 | 70 | 237 | 3.39 | 2 | 70.00 | 237.00 |