2025 Big 12 Conference Leaders Sacks - Games vs. Ranked Teams Only (AP Poll) through 09/12/2025
| Name | Team | Yr | Pos | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Tobi Osunsanmi | Kansas St | JR | DE | 1 | 2.0 | 18 | 2.00 |
| 2 | Leroy Harris III | Kansas | SO | DE | 1 | 1.5 | 4 | 1.50 |
| 3 | Kendrick Simpkins | Baylor | SR | S | 1 | 1.0 | 14 | 1.00 |
| 3 | Qua Moss | Kansas St | JR | S | 1 | 1.0 | 10 | 1.00 |
| 3 | Jordan Allen | Kansas St | SO | DE | 1 | 1.0 | 4 | 1.00 |
| 3 | Kenean Caldwell | Kansas | SR | DT | 1 | 1.0 | 2 | 1.00 |
| 7 | Trey Lathan | Kansas | JR | LB | 1 | 0.5 | 4 | 0.50 |
| 7 | Tommy Dunn Jr. | Kansas | SR | DT | 1 | 0.5 | 2 | 0.50 |
| 7 | Jon Jon Kamara | Kansas | FR | LB | 1 | 0.5 | 1 | 0.50 |