2025 Conference USA Leaders Sacks - Games vs. FBS non-Power 5 Conference Teams Only through 11/01/2025
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | UTEP | 6 | 16.0 | 110 | 2.67 |
| 2 | Middle Tennessee State | 6 | 13.0 | 88 | 2.17 |
| 2 | Jacksonville State | 6 | 13.0 | 75 | 2.17 |
| 2 | New Mexico State | 7 | 13.0 | 74 | 1.86 |
| 5 | FIU | 6 | 10.0 | 73 | 1.67 |
| 5 | Kennesaw State | 5 | 10.0 | 55 | 2.00 |
| 7 | Missouri State | 5 | 9.0 | 63 | 1.80 |
| 8 | Sam Houston State | 7 | 8.0 | 50 | 1.14 |
| 8 | Liberty | 7 | 8.0 | 40 | 1.14 |
| 10 | Delaware | 6 | 7.0 | 47 | 1.17 |
| 10 | Western Kentucky | 8 | 7.0 | 39 | 0.88 |
| 12 | Louisiana Tech | 6 | 6.0 | 33 | 1.00 |