2025 Conference USA Leaders Total Offense - Games vs. FBS Power 5 Conference Teams Only through 11/22/2025
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Delaware | 2 | 151 | 545 | 142 | 696 | 4.90 | 348.0 |
| 2 | Missouri State | 2 | 118 | 434 | 122 | 552 | 4.52 | 276.0 |
| 3 | Kennesaw State | 2 | 247 | 331 | 129 | 578 | 4.48 | 289.0 |
| 4 | New Mexico State | 1 | 27 | 313 | 83 | 340 | 4.10 | 340.0 |
| 5 | UTEP | 1 | 50 | 209 | 59 | 259 | 4.39 | 259.0 |
| 6 | Middle Tennessee State | 1 | 33 | 208 | 60 | 241 | 4.02 | 241.0 |
| 7 | Sam Houston State | 2 | 99 | 171 | 99 | 270 | 2.73 | 135.0 |
| 8 | Jacksonville State | 1 | 165 | 157 | 69 | 322 | 4.67 | 322.0 |
| 9 | Louisiana Tech | 2 | 165 | 156 | 104 | 321 | 3.09 | 160.5 |
| 10 | FIU | 1 | 141 | 149 | 72 | 290 | 4.03 | 290.0 |
| 11 | Western Kentucky | 1 | 22 | 130 | 65 | 152 | 2.34 | 152.0 |