2025 Conference USA Leaders Total Offense - Games vs. FBS Power 5 Conference Teams Only through 11/01/2025
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Delaware | 1 | 84 | 312 | 66 | 396 | 6.00 | 396.0 |
| 2 | Jacksonville State | 1 | 165 | 157 | 69 | 322 | 4.67 | 322.0 |
| 3 | FIU | 1 | 141 | 149 | 72 | 290 | 4.03 | 290.0 |
| 4 | Kennesaw State | 2 | 247 | 331 | 129 | 578 | 4.48 | 289.0 |
| 5 | Missouri State | 2 | 118 | 434 | 122 | 552 | 4.52 | 276.0 |
| 6 | UTEP | 1 | 50 | 209 | 59 | 259 | 4.39 | 259.0 |
| 7 | Middle Tennessee State | 1 | 33 | 208 | 60 | 241 | 4.02 | 241.0 |
| 8 | Louisiana Tech | 1 | 58 | 96 | 53 | 154 | 2.91 | 154.0 |
| 9 | Sam Houston State | 1 | 27 | 86 | 51 | 113 | 2.22 | 113.0 |