2025 Conference USA Leaders Scoring Defense - Games vs. FBS non-Power 5 Conference Teams Only through 11/01/2025
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Kennesaw State | 5 | 11 | 5 | 9 | 0 | 0 | 90 | 18.0 |
| 2 | Missouri State | 5 | 12 | 7 | 12 | 0 | 0 | 105 | 21.0 |
| 3 | Louisiana Tech | 6 | 15 | 5 | 13 | 2 | 0 | 122 | 20.3 |
| 4 | UTEP | 6 | 18 | 10 | 16 | 1 | 1 | 158 | 26.3 |
| 5 | Middle Tennessee State | 6 | 19 | 8 | 18 | 0 | 0 | 156 | 26.0 |
| 6 | Liberty | 7 | 20 | 11 | 17 | 2 | 0 | 174 | 24.9 |
| 7 | Western Kentucky | 8 | 21 | 18 | 19 | 0 | 0 | 199 | 24.9 |
| 8 | New Mexico State | 7 | 25 | 8 | 24 | 1 | 0 | 200 | 28.6 |
| 8 | Jacksonville State | 6 | 25 | 3 | 19 | 1 | 0 | 180 | 30.0 |
| 8 | FIU | 6 | 25 | 7 | 25 | 0 | 0 | 196 | 32.7 |
| 11 | Delaware | 6 | 27 | 7 | 26 | 0 | 0 | 209 | 34.8 |
| 12 | Sam Houston State | 7 | 34 | 12 | 32 | 0 | 0 | 272 | 38.9 |