2022 American Athletic Conference Leaders Total Defense - Games in December/January Only through 01/09/2023
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Navy | 1 | 125 | 28 | 60 | 153 | 2.55 | 153.0 |
| 2 | SMU | 1 | 209 | 47 | 54 | 256 | 4.74 | 256.0 |
| 3 | Memphis | 1 | 126 | 135 | 58 | 261 | 4.50 | 261.0 |
| 4 | Houston | 1 | 129 | 194 | 64 | 323 | 5.05 | 323.0 |
| 5 | East Carolina | 1 | 125 | 212 | 63 | 337 | 5.35 | 337.0 |
| 6 | Cincinnati | 1 | 287 | 132 | 72 | 419 | 5.82 | 419.0 |
| 7 | UCF | 2 | 431 | 567 | 133 | 998 | 7.50 | 499.0 |
| 8 | Tulane | 2 | 277 | 727 | 180 | 1004 | 5.58 | 502.0 |