2022 American Athletic Conference Leaders Total Defense - Games vs. Conference Teams Only through 01/09/2023
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Cincinnati | 8 | 1204 | 1507 | 565 | 2711 | 4.80 | 338.9 |
| 2 | Memphis | 8 | 1067 | 1882 | 562 | 2949 | 5.25 | 368.6 |
| 3 | Navy | 8 | 663 | 2360 | 472 | 3023 | 6.40 | 377.9 |
| 4 | Tulane | 9 | 1495 | 2041 | 685 | 3536 | 5.16 | 392.9 |
| 5 | UCF | 9 | 1458 | 2260 | 621 | 3718 | 5.99 | 413.1 |
| 6 | Houston | 8 | 1138 | 2249 | 557 | 3387 | 6.08 | 423.4 |
| 7 | Tulsa | 8 | 1710 | 1720 | 569 | 3430 | 6.03 | 428.8 |
| 8 | East Carolina | 8 | 842 | 2664 | 552 | 3506 | 6.35 | 438.3 |
| 9 | Temple | 8 | 1791 | 1833 | 581 | 3624 | 6.24 | 453.0 |
| 10 | SMU | 8 | 1716 | 2036 | 597 | 3752 | 6.28 | 469.0 |
| 11 | South Florida | 8 | 1835 | 2502 | 565 | 4337 | 7.68 | 542.1 |