2022 Atlantic Coast Conference Leaders Total Defense - Games in October Only through 01/09/2023
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Clemson | 4 | 389 | 886 | 271 | 1275 | 4.70 | 318.8 |
| 2 | Louisville | 4 | 410 | 1085 | 272 | 1495 | 5.50 | 373.8 |
| 3 | Duke | 4 | 477 | 1093 | 277 | 1570 | 5.67 | 392.5 |
| 4 | Boston College | 4 | 513 | 911 | 272 | 1424 | 5.24 | 356.0 |
| 5 | Miami (Florida) | 4 | 558 | 832 | 260 | 1390 | 5.35 | 347.5 |
| 6 | Pittsburgh | 4 | 566 | 957 | 280 | 1523 | 5.44 | 380.8 |
| 7 | North Carolina | 4 | 569 | 1151 | 285 | 1720 | 6.04 | 430.0 |
| 8 | North Carolina State | 4 | 580 | 843 | 229 | 1423 | 6.21 | 355.8 |
| 9 | Florida State | 4 | 586 | 760 | 282 | 1346 | 4.77 | 336.5 |
| 10 | Wake Forest | 4 | 604 | 921 | 270 | 1525 | 5.65 | 381.3 |
| 11 | Virginia | 4 | 649 | 675 | 291 | 1324 | 4.55 | 331.0 |
| 12 | Georgia Tech | 4 | 650 | 1092 | 306 | 1742 | 5.69 | 435.5 |
| 13 | Virginia Tech | 4 | 653 | 1184 | 295 | 1837 | 6.23 | 459.3 |
| 14 | Syracuse | 4 | 665 | 452 | 267 | 1117 | 4.18 | 279.3 |