2022 Atlantic Coast Conference Leaders Total Defense - Games vs. Unranked Teams Only (AP Poll) through 01/09/2023
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Clemson | 10 | 790 | 2294 | 654 | 3084 | 4.72 | 308.4 |
| 2 | Syracuse | 9 | 948 | 1764 | 569 | 2712 | 4.77 | 301.3 |
| 3 | North Carolina State | 11 | 958 | 2551 | 725 | 3509 | 4.84 | 319.0 |
| 4 | Miami (Florida) | 9 | 1027 | 2070 | 549 | 3097 | 5.64 | 344.1 |
| 5 | Pittsburgh | 11 | 1055 | 2365 | 696 | 3420 | 4.91 | 310.9 |
| 6 | Louisville | 10 | 1137 | 1946 | 645 | 3083 | 4.78 | 308.3 |
| 7 | Virginia Tech | 10 | 1161 | 2426 | 684 | 3587 | 5.24 | 358.7 |
| 8 | Virginia | 9 | 1343 | 1836 | 647 | 3179 | 4.91 | 353.2 |
| 9 | Boston College | 9 | 1404 | 1808 | 613 | 3212 | 5.24 | 356.9 |
| 10 | Duke | 12 | 1452 | 3155 | 826 | 4607 | 5.58 | 383.9 |
| 11 | Wake Forest | 11 | 1464 | 2837 | 781 | 4301 | 5.51 | 391.0 |
| 12 | Georgia Tech | 8 | 1535 | 1446 | 569 | 2981 | 5.24 | 372.6 |
| 13 | North Carolina | 10 | 1618 | 2751 | 731 | 4369 | 5.98 | 436.9 |
| 14 | Florida State | 11 | 1727 | 1738 | 731 | 3465 | 4.74 | 315.0 |