2022 Atlantic Coast Conference Leaders Rushing Defense - Games vs. Unranked Teams Only (AP Poll) through 01/09/2023
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Clemson | 10 | 292 | 790 | 2.71 | 5 | 29.20 | 79.00 |
| 2 | Syracuse | 9 | 299 | 948 | 3.17 | 8 | 33.22 | 105.33 |
| 3 | North Carolina State | 11 | 324 | 958 | 2.96 | 10 | 29.45 | 87.09 |
| 4 | Miami (Florida) | 9 | 295 | 1027 | 3.48 | 9 | 32.78 | 114.11 |
| 5 | Pittsburgh | 11 | 321 | 1055 | 3.29 | 9 | 29.18 | 95.91 |
| 6 | Louisville | 10 | 367 | 1137 | 3.10 | 8 | 36.70 | 113.70 |
| 7 | Virginia Tech | 10 | 338 | 1161 | 3.43 | 9 | 33.80 | 116.10 |
| 8 | Virginia | 9 | 359 | 1343 | 3.74 | 11 | 39.89 | 149.22 |
| 9 | Boston College | 9 | 353 | 1404 | 3.98 | 16 | 39.22 | 156.00 |
| 10 | Duke | 12 | 393 | 1452 | 3.69 | 9 | 32.75 | 121.00 |
| 11 | Wake Forest | 11 | 391 | 1464 | 3.74 | 13 | 35.55 | 133.09 |
| 12 | Georgia Tech | 8 | 345 | 1535 | 4.45 | 13 | 43.13 | 191.88 |
| 13 | North Carolina | 10 | 379 | 1618 | 4.27 | 18 | 37.90 | 161.80 |
| 14 | Florida State | 11 | 440 | 1727 | 3.93 | 12 | 40.00 | 157.00 |