2022 Big 12 Conference Leaders Interceptions - Games in August/September Only through 01/09/2023
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Josh Newton | TCU | JR | CB | 3 | 2 | 57 | 0 | 0.67 |
| 1 | Colby Reeder | Iowa State | SR | LB | 4 | 2 | 66 | 0 | 0.50 |
| 1 | Daniel Green | Kansas St | SR | LB | 4 | 2 | 50 | 0 | 0.50 |
| 1 | Reggie Pearson Jr. | Texas Tech | SR | DB | 4 | 2 | 36 | 0 | 0.50 |
| 1 | Kobe Savage | Kansas St | JR | S | 4 | 2 | 0 | 0 | 0.50 |
| 1 | Cincere Mason | Kansas St | SR | S | 4 | 2 | 0 | 0 | 0.50 |
| 7 | Christian Morgan | Baylor | SR | S | 2 | 1 | 0 | 0 | 0.50 |
| 7 | Jacolby Spells | WVU | FR | DB | 3 | 1 | 27 | 1 | 0.33 |
| 7 | Kendal Daniels | Okla St | FR | S | 3 | 1 | 0 | 0 | 0.33 |
| 7 | Key Lawrence | Oklahoma | JR | DB | 3 | 1 | 0 | 0 | 0.33 |
| 7 | Abe Camara | TCU | JR | S | 3 | 1 | 0 | 0 | 0.33 |
| 7 | Jaionte McMillan | TCU | SO | CB | 3 | 1 | 0 | 0 | 0.33 |
| 7 | Cobee Bryant | Kansas | SO | CB | 4 | 1 | 86 | 1 | 0.25 |
| 7 | D'Shawn Jamison | Texas | SR | DB | 4 | 1 | 69 | 1 | 0.25 |
| 7 | Jahdae Barron | Texas | JR | DB | 4 | 1 | 44 | 1 | 0.25 |
| 7 | Kenny Logan Jr. | Kansas | SR | S | 4 | 1 | 26 | 0 | 0.25 |
| 7 | Justin Harrington | Oklahoma | SR | DB | 4 | 1 | 22 | 0 | 0.25 |
| 7 | Eriq Gilyard | Kansas | SR | LB | 4 | 1 | 11 | 0 | 0.25 |
| 7 | Nick Allen | Kansas St | SR | LB | 4 | 1 | 2 | 0 | 0.25 |
| 7 | Devin Neal | Baylor | JR | S | 4 | 1 | 0 | 0 | 0.25 |
| 7 | Anthony Johnson Jr. | Iowa State | SR | DB | 4 | 1 | 0 | 0 | 0.25 |
| 7 | Tyler Onyedim | Iowa State | FR | DL | 4 | 1 | 0 | 0 | 0.25 |
| 7 | Gentry Williams | Oklahoma | FR | DB | 4 | 1 | 0 | 0 | 0.25 |