2021 National Leaders Passes Defended - Games in December/January Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Georgia | 3 | 4 | 15 | 19 | 6.33 |
| 2 | Alabama | 3 | 2 | 12 | 14 | 4.67 |
| 3 | Baylor | 2 | 7 | 11 | 18 | 9.00 |
| 3 | Oklahoma State | 2 | 1 | 11 | 12 | 6.00 |
| 5 | Utah State | 2 | 1 | 9 | 10 | 5.00 |
| 5 | Appalachian State | 2 | 0 | 9 | 9 | 4.50 |
| 7 | Pittsburgh | 2 | 5 | 8 | 13 | 6.50 |
| 7 | San Diego State | 2 | 2 | 8 | 10 | 5.00 |
| 7 | Middle Tennessee | 1 | 1 | 8 | 9 | 9.00 |
| 10 | Utah | 2 | 3 | 7 | 10 | 5.00 |
| 10 | Texas Tech | 1 | 1 | 7 | 8 | 8.00 |
| 10 | Louisiana-Lafayette | 2 | 1 | 7 | 8 | 4.00 |
| 13 | UTSA | 2 | 2 | 6 | 8 | 4.00 |
| 13 | Wake Forest | 2 | 2 | 6 | 8 | 4.00 |
| 13 | Western Kentucky | 2 | 2 | 6 | 8 | 4.00 |
| 13 | Minnesota | 1 | 1 | 6 | 7 | 7.00 |
| 13 | California | 1 | 0 | 6 | 6 | 6.00 |
| 13 | UCF | 1 | 0 | 6 | 6 | 6.00 |
| 13 | Rutgers | 1 | 0 | 6 | 6 | 6.00 |
| 20 | Tennessee | 1 | 3 | 5 | 8 | 8.00 |
| 20 | Mississippi | 1 | 1 | 5 | 6 | 6.00 |
| 20 | Washington State | 1 | 1 | 5 | 6 | 6.00 |
| 20 | Marshall | 1 | 0 | 5 | 5 | 5.00 |
| 20 | Navy | 1 | 0 | 5 | 5 | 5.00 |
| 25 | Iowa | 2 | 3 | 4 | 7 | 3.50 |
| 25 | Oregon State | 1 | 2 | 4 | 6 | 6.00 |
| 25 | Cincinnati | 2 | 2 | 4 | 6 | 3.00 |
| 25 | Clemson | 1 | 1 | 4 | 5 | 5.00 |
| 25 | Iowa State | 1 | 1 | 4 | 5 | 5.00 |
| 25 | Nevada | 1 | 1 | 4 | 5 | 5.00 |
| 25 | LSU | 1 | 0 | 4 | 4 | 4.00 |
| 32 | Kentucky | 1 | 3 | 3 | 6 | 6.00 |
| 32 | Arkansas | 1 | 2 | 3 | 5 | 5.00 |
| 32 | Auburn | 1 | 2 | 3 | 5 | 5.00 |
| 32 | Eastern Michigan | 1 | 1 | 3 | 4 | 4.00 |
| 32 | Liberty | 1 | 1 | 3 | 4 | 4.00 |
| 32 | Toledo | 1 | 1 | 3 | 4 | 4.00 |
| 32 | Tulsa | 1 | 1 | 3 | 4 | 4.00 |
| 32 | Western Michigan | 1 | 1 | 3 | 4 | 4.00 |
| 32 | Michigan | 2 | 1 | 3 | 4 | 2.00 |
| 32 | Mississippi State | 1 | 0 | 3 | 3 | 3.00 |
| 32 | Purdue | 1 | 0 | 3 | 3 | 3.00 |
| 32 | South Carolina | 1 | 0 | 3 | 3 | 3.00 |
| 32 | UTEP | 1 | 0 | 3 | 3 | 3.00 |
| 32 | Air Force | 1 | 0 | 3 | 3 | 3.00 |
| 32 | Houston | 2 | 0 | 3 | 3 | 1.50 |
| 32 | Army | 2 | 0 | 3 | 3 | 1.50 |
| 48 | Kansas State | 1 | 2 | 2 | 4 | 4.00 |
| 48 | Miami (Ohio) | 1 | 2 | 2 | 4 | 4.00 |
| 48 | BYU | 1 | 1 | 2 | 3 | 3.00 |
| 48 | Fresno State | 1 | 1 | 2 | 3 | 3.00 |
| 48 | Central Michigan | 1 | 0 | 2 | 2 | 2.00 |
| 48 | Florida | 1 | 0 | 2 | 2 | 2.00 |
| 48 | Maryland | 1 | 0 | 2 | 2 | 2.00 |
| 48 | Old Dominion | 1 | 0 | 2 | 2 | 2.00 |
| 48 | Wyoming | 1 | 0 | 2 | 2 | 2.00 |
| 57 | Penn State | 1 | 2 | 1 | 3 | 3.00 |
| 57 | Northern Illinois | 2 | 2 | 1 | 3 | 1.50 |
| 57 | Oregon | 2 | 2 | 1 | 3 | 1.50 |
| 57 | Arizona State | 1 | 1 | 1 | 2 | 2.00 |
| 57 | Georgia State | 1 | 1 | 1 | 2 | 2.00 |
| 57 | Michigan State | 1 | 1 | 1 | 2 | 2.00 |
| 57 | Oklahoma | 1 | 1 | 1 | 2 | 2.00 |
| 57 | West Virginia | 1 | 1 | 1 | 2 | 2.00 |
| 57 | Kent State | 2 | 1 | 1 | 2 | 1.00 |
| 57 | UAB | 1 | 0 | 1 | 1 | 1.00 |
| 57 | Coastal Carolina | 1 | 0 | 1 | 1 | 1.00 |
| 57 | Missouri | 1 | 0 | 1 | 1 | 1.00 |
| 57 | North Carolina | 1 | 0 | 1 | 1 | 1.00 |
| 57 | Ohio State | 1 | 0 | 1 | 1 | 1.00 |
| 71 | Wisconsin | 1 | 1 | 0 | 1 | 1.00 |