2021 Pac-12 Conference Leaders Long All Purpose Plays - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
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| Name | Team | Yr | Pos | G | Yards | Yards | Yards | Yards | Yards | Yards | Yards | |
| 1 | Britain Covey | Utah | JR | WR | 5 | 6 | 3 | 3 | 3 | 3 | 2 | 1 |
| 2 | Cameron Rising | Utah | SO | QB | 4 | 2 | 2 | 1 | 1 | 0 | 0 | 0 |
| 3 | B.J. Baylor | Oregon St | JR | RB | 3 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 3 | Micah Bernard | Utah | FR | RB | 5 | 2 | 1 | 1 | 0 | 0 | 0 | 0 |
| 3 | Stanley Berryhill III | Arizona | JR | WR | 4 | 2 | 1 | 0 | 0 | 0 | 0 | 0 |
| 3 | Max Borghi | Wash St | SR | RB | 4 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 3 | Carson Bruener | Washington | FR | LB | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| 3 | Gary Bryant Jr. | USC | SO | WR | 3 | 2 | 1 | 1 | 1 | 0 | 0 | 0 |
| 3 | LV Bunkley-Shelton | Ariz St | FR | WR | 2 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| 3 | Terrell Bynum | Washington | JR | WR | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| 3 | Chase Cota | UCLA | SR | WR | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| 3 | Tayvian Cunningham | Arizona | SR | WR | 4 | 2 | 1 | 1 | 0 | 0 | 0 | 0 |
| 3 | Malcolm Epps | USC | JR | TE | 3 | 2 | 1 | 0 | 0 | 0 | 0 | 0 |
| 3 | Tre'Shaun Harrison | Oregon St | JR | WR | 3 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| 3 | Kris Hutson | Oregon | FR | WR | 4 | 3 | 1 | 1 | 0 | 0 | 0 | 0 |
| 3 | Giles Jackson | Washington | SO | WR | 2 | 2 | 1 | 0 | 0 | 0 | 0 | 0 |
| 3 | Calvin Jackson Jr. | Wash St | SR | WR | 4 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 3 | Andre Johnson | Ariz St | SO | WR | 2 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| 3 | Brant Kuithe | Utah | JR | TE | 5 | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| 3 | Drake London | USC | JR | WR | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| 3 | Mark Perry | Colorado | SO | S | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| 3 | Will Plummer | Arizona | FR | QB | 3 | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| 3 | Nikko Reed | Colorado | FR | CB | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 3 | Merlin Robertson | Ariz St | SR | LB | 2 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 3 | Dorian Singer | Arizona | FR | WR | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| 3 | Dont'e Thornton | Oregon | FR | WR | 4 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 3 | CJ Verdell | Oregon | JR | RB | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 3 | Jaylen Watson | Wash St | SR | DB | 4 | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| 3 | Benjamin Yurosek | Stanford | SO | TE | 3 | 1 | 1 | 0 | 0 | 0 | 0 | 0 |