2021 Mid-American Conference Leaders Sacks - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Central Michigan | 3 | 9.0 | 83 | 3.00 |
| 2 | Bowling Green | 2 | 7.0 | 54 | 3.50 |
| 3 | Northern Illinois | 2 | 4.0 | 22 | 2.00 |
| 4 | Western Michigan | 2 | 3.0 | 33 | 1.50 |
| 4 | Ball State | 1 | 3.0 | 18 | 3.00 |
| 4 | Kent State | 3 | 3.0 | 9 | 1.00 |
| 7 | Akron | 2 | 2.0 | 15 | 1.00 |
| 8 | Miami (Ohio) | 1 | 1.0 | 8 | 1.00 |
| 8 | Eastern Michigan | 1 | 1.0 | 5 | 1.00 |
| 8 | Ohio | 2 | 1.0 | 3 | 0.50 |