2021 Mid-American Conference Leaders Rushing Defense - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Toledo | 12 | 483 | 1822 | 3.77 | 11 | 40.25 | 151.83 |
| 2 | Central Michigan | 9 | 351 | 1189 | 3.39 | 14 | 39.00 | 132.11 |
| 2 | Western Michigan | 10 | 327 | 1448 | 4.43 | 14 | 32.70 | 144.80 |
| 4 | Miami (Ohio) | 11 | 398 | 1684 | 4.23 | 16 | 36.18 | 153.09 |
| 5 | Ohio | 9 | 338 | 1492 | 4.41 | 17 | 37.56 | 165.78 |
| 6 | Ball State | 11 | 456 | 1983 | 4.35 | 19 | 41.45 | 180.27 |
| 7 | Eastern Michigan | 11 | 419 | 2142 | 5.11 | 21 | 38.09 | 194.73 |
| 7 | Northern Illinois | 11 | 388 | 2234 | 5.76 | 21 | 35.27 | 203.09 |
| 7 | Akron | 9 | 384 | 2405 | 6.26 | 21 | 42.67 | 267.22 |
| 10 | Bowling Green | 9 | 401 | 1672 | 4.17 | 24 | 44.56 | 185.78 |
| 10 | Buffalo | 10 | 413 | 2101 | 5.09 | 24 | 41.30 | 210.10 |
| 12 | Kent State | 10 | 434 | 2093 | 4.82 | 32 | 43.40 | 209.30 |