2021 Mid-American Conference Leaders Rushing Defense - Games vs. Conference Teams Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Miami (Ohio) | 8 | 272 | 964 | 3.54 | 8 | 34.00 | 120.50 |
| 1 | Toledo | 8 | 325 | 1299 | 4.00 | 8 | 40.63 | 162.38 |
| 3 | Ohio | 8 | 289 | 1182 | 4.09 | 12 | 36.13 | 147.75 |
| 3 | Western Michigan | 8 | 266 | 1267 | 4.76 | 12 | 33.25 | 158.38 |
| 5 | Central Michigan | 8 | 319 | 1147 | 3.60 | 13 | 39.88 | 143.38 |
| 5 | Ball State | 8 | 315 | 1334 | 4.23 | 13 | 39.38 | 166.75 |
| 7 | Northern Illinois | 9 | 318 | 1844 | 5.80 | 15 | 35.33 | 204.89 |
| 8 | Eastern Michigan | 8 | 313 | 1588 | 5.07 | 16 | 39.13 | 198.50 |
| 9 | Buffalo | 8 | 326 | 1672 | 5.13 | 19 | 40.75 | 209.00 |
| 9 | Akron | 8 | 350 | 2228 | 6.37 | 19 | 43.75 | 278.50 |
| 11 | Bowling Green | 8 | 364 | 1558 | 4.28 | 22 | 45.50 | 194.75 |
| 12 | Kent State | 9 | 382 | 1682 | 4.40 | 26 | 42.44 | 186.89 |