2021 Mid-American Conference Leaders Rushing Defense - Games in October Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Miami (Ohio) | 4 | 115 | 268 | 2.33 | 0 | 28.75 | 67.00 |
| 2 | Toledo | 4 | 157 | 559 | 3.56 | 3 | 39.25 | 139.75 |
| 3 | Northern Illinois | 4 | 103 | 523 | 5.08 | 4 | 25.75 | 130.75 |
| 4 | Western Michigan | 4 | 134 | 512 | 3.82 | 6 | 33.50 | 128.00 |
| 4 | Ohio | 4 | 164 | 662 | 4.04 | 6 | 41.00 | 165.50 |
| 4 | Central Michigan | 4 | 177 | 680 | 3.84 | 6 | 44.25 | 170.00 |
| 7 | Ball State | 4 | 175 | 504 | 2.88 | 8 | 43.75 | 126.00 |
| 7 | Akron | 4 | 169 | 981 | 5.80 | 8 | 42.25 | 245.25 |
| 9 | Eastern Michigan | 4 | 151 | 698 | 4.62 | 9 | 37.75 | 174.50 |
| 10 | Buffalo | 5 | 209 | 1125 | 5.38 | 12 | 41.80 | 225.00 |
| 11 | Kent State | 4 | 165 | 843 | 5.11 | 13 | 41.25 | 210.75 |
| 12 | Bowling Green | 5 | 257 | 1050 | 4.09 | 14 | 51.40 | 210.00 |