2021 Mid-American Conference Leaders Rushing Defense - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Central Michigan | 3 | 86 | 308 | 3.58 | 4 | 28.67 | 102.67 |
| 2 | Western Michigan | 2 | 67 | 410 | 6.12 | 3 | 33.50 | 205.00 |
| 2 | Akron | 2 | 67 | 553 | 8.25 | 10 | 33.50 | 276.50 |
| 4 | Kent State | 3 | 108 | 651 | 6.03 | 7 | 36.00 | 217.00 |
| 5 | Buffalo | 1 | 41 | 220 | 5.37 | 2 | 41.00 | 220.00 |
| 6 | Miami (Ohio) | 1 | 46 | 175 | 3.80 | 2 | 46.00 | 175.00 |
| 7 | Ohio | 2 | 95 | 656 | 6.91 | 7 | 47.50 | 328.00 |
| 8 | Ball State | 1 | 48 | 240 | 5.00 | 2 | 48.00 | 240.00 |
| 9 | Northern Illinois | 2 | 99 | 644 | 6.51 | 10 | 49.50 | 322.00 |
| 10 | Bowling Green | 2 | 108 | 513 | 4.75 | 5 | 54.00 | 256.50 |
| 11 | Eastern Michigan | 1 | 55 | 352 | 6.40 | 4 | 55.00 | 352.00 |