2021 Mid-American Conference Leaders Rushing Defense - Games vs. FBS Teams With Winning Record Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Ohio | 5 | 172 | 940 | 5.47 | 13 | 34.40 | 188.00 |
| 2 | Northern Illinois | 7 | 243 | 1423 | 5.86 | 18 | 34.71 | 203.29 |
| 3 | Western Michigan | 7 | 244 | 1394 | 5.71 | 11 | 34.86 | 199.14 |
| 4 | Central Michigan | 6 | 228 | 688 | 3.02 | 8 | 38.00 | 114.67 |
| 5 | Miami (Ohio) | 5 | 200 | 909 | 4.55 | 8 | 40.00 | 181.80 |
| 6 | Akron | 4 | 161 | 1079 | 6.70 | 13 | 40.25 | 269.75 |
| 7 | Toledo | 6 | 250 | 957 | 3.83 | 9 | 41.67 | 159.50 |
| 8 | Eastern Michigan | 7 | 294 | 1578 | 5.37 | 15 | 42.00 | 225.43 |
| 9 | Ball State | 10 | 434 | 1948 | 4.49 | 20 | 43.40 | 194.80 |
| 10 | Buffalo | 4 | 174 | 894 | 5.14 | 8 | 43.50 | 223.50 |
| 11 | Kent State | 9 | 394 | 2165 | 5.49 | 31 | 43.78 | 240.56 |
| 12 | Bowling Green | 6 | 285 | 1350 | 4.74 | 16 | 47.50 | 225.00 |