2021 Mid-American Conference Leaders Total Defense - Games vs. FBS (I-A) Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Western Michigan | 12 | 1858 | 2394 | 696 | 4252 | 6.11 | 354.3 |
| 2 | Toledo | 12 | 1822 | 2449 | 872 | 4271 | 4.90 | 355.9 |
| 3 | Bowling Green | 11 | 2185 | 2102 | 789 | 4287 | 5.43 | 389.7 |
| 4 | Miami (Ohio) | 12 | 1859 | 2715 | 806 | 4574 | 5.67 | 381.2 |
| 5 | Ohio | 11 | 2148 | 2677 | 786 | 4825 | 6.14 | 438.6 |
| 6 | Central Michigan | 12 | 1497 | 3367 | 851 | 4864 | 5.72 | 405.3 |
| 7 | Buffalo | 11 | 2321 | 2572 | 737 | 4893 | 6.64 | 444.8 |
| 8 | Ball State | 12 | 2223 | 2743 | 859 | 4966 | 5.78 | 413.8 |
| 9 | Eastern Michigan | 12 | 2494 | 2883 | 838 | 5377 | 6.42 | 448.1 |
| 10 | Akron | 11 | 2958 | 2505 | 727 | 5463 | 7.51 | 496.6 |
| 11 | Northern Illinois | 13 | 2878 | 3167 | 869 | 6045 | 6.96 | 465.0 |
| 12 | Kent State | 13 | 2744 | 3578 | 993 | 6322 | 6.37 | 486.3 |