2021 Mid-American Conference Leaders Total Defense - Games vs. FBS Teams With Winning Record Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Miami (Ohio) | 5 | 909 | 991 | 328 | 1900 | 5.79 | 380.0 |
| 2 | Buffalo | 4 | 894 | 1059 | 281 | 1953 | 6.95 | 488.3 |
| 3 | Akron | 4 | 1079 | 1132 | 269 | 2211 | 8.22 | 552.8 |
| 4 | Central Michigan | 6 | 688 | 1633 | 437 | 2321 | 5.31 | 386.8 |
| 5 | Bowling Green | 6 | 1350 | 1063 | 407 | 2413 | 5.93 | 402.2 |
| 6 | Ohio | 5 | 940 | 1505 | 364 | 2445 | 6.72 | 489.0 |
| 7 | Toledo | 6 | 957 | 1543 | 457 | 2500 | 5.47 | 416.7 |
| 8 | Western Michigan | 7 | 1394 | 1329 | 395 | 2723 | 6.89 | 389.0 |
| 9 | Eastern Michigan | 7 | 1578 | 1679 | 499 | 3257 | 6.53 | 465.3 |
| 10 | Northern Illinois | 7 | 1423 | 1968 | 452 | 3391 | 7.50 | 484.4 |
| 11 | Ball State | 10 | 1948 | 2224 | 718 | 4172 | 5.81 | 417.2 |
| 12 | Kent State | 9 | 2165 | 2645 | 690 | 4810 | 6.97 | 534.4 |