2021 Mid-American Conference Leaders Total Defense - Games in November Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Bowling Green | 3 | 508 | 600 | 176 | 1108 | 6.30 | 369.3 |
| 2 | Buffalo | 3 | 547 | 724 | 203 | 1271 | 6.26 | 423.7 |
| 3 | Central Michigan | 4 | 467 | 989 | 290 | 1456 | 5.02 | 364.0 |
| 4 | Toledo | 4 | 641 | 855 | 294 | 1496 | 5.09 | 374.0 |
| 5 | Western Michigan | 4 | 755 | 746 | 228 | 1501 | 6.58 | 375.3 |
| 6 | Miami (Ohio) | 4 | 696 | 978 | 286 | 1674 | 5.85 | 418.5 |
| 7 | Ohio | 4 | 520 | 1251 | 290 | 1771 | 6.11 | 442.8 |
| 8 | Ball State | 4 | 771 | 1015 | 292 | 1786 | 6.12 | 446.5 |
| 9 | Kent State | 4 | 573 | 1332 | 313 | 1905 | 6.09 | 476.3 |
| 10 | Eastern Michigan | 4 | 890 | 1105 | 281 | 1995 | 7.10 | 498.8 |
| 11 | Akron | 4 | 1247 | 769 | 282 | 2016 | 7.15 | 504.0 |
| 12 | Northern Illinois | 4 | 1126 | 948 | 284 | 2074 | 7.30 | 518.5 |