2021 Mid-American Conference Leaders Passing Defense - Games in August/September Only through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Bowling Green | 4 | 111 | 59 | 53.2 | 592 | 5.3 | 1 | 5 | 91.91 | 27.8 | 148.0 |
| 2 | Toledo | 4 | 119 | 65 | 54.6 | 751 | 6.3 | 4 | 2 | 115.36 | 29.8 | 187.8 |
| 3 | Western Michigan | 4 | 96 | 55 | 57.3 | 719 | 7.5 | 9 | 3 | 144.90 | 24.0 | 179.8 |
| 4 | Northern Illinois | 4 | 93 | 55 | 59.1 | 760 | 8.2 | 4 | 0 | 141.97 | 23.3 | 190.0 |
| 5 | Eastern Michigan | 4 | 114 | 69 | 60.5 | 850 | 7.5 | 5 | 3 | 132.37 | 28.5 | 212.5 |
| 6 | Buffalo | 4 | 94 | 57 | 60.6 | 828 | 8.8 | 6 | 2 | 151.44 | 23.5 | 207.0 |
| 7 | Miami (Ohio) | 4 | 69 | 43 | 62.3 | 585 | 8.5 | 7 | 2 | 161.22 | 17.3 | 146.3 |
| 8 | Central Michigan | 4 | 121 | 77 | 63.6 | 1107 | 9.1 | 9 | 2 | 161.73 | 30.3 | 276.8 |
| 9 | Kent State | 4 | 148 | 95 | 64.2 | 1034 | 7.0 | 6 | 9 | 124.09 | 37.0 | 258.5 |
| 10 | Ball State | 4 | 117 | 78 | 66.7 | 993 | 8.5 | 6 | 2 | 151.46 | 29.3 | 248.3 |
| 11 | Ohio | 4 | 106 | 72 | 67.9 | 634 | 6.0 | 3 | 1 | 125.62 | 26.5 | 158.5 |
| 12 | Akron | 4 | 101 | 76 | 75.2 | 1054 | 10.4 | 8 | 1 | 187.07 | 25.3 | 263.5 |