2021 Mid-American Conference Leaders Total Defense - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Kent State | 1 | 206 | 212 | 75 | 418 | 5.57 | 418.0 |
| 2 | Northern Illinois | 1 | 373 | 233 | 65 | 606 | 9.32 | 606.0 |
| 3 | Ohio | 1 | 310 | 252 | 83 | 562 | 6.77 | 562.0 |
| 4 | Miami (Ohio) | 1 | 247 | 295 | 57 | 542 | 9.51 | 542.0 |
| 5 | Toledo | 1 | 132 | 317 | 75 | 449 | 5.99 | 449.0 |
| 6 | Akron | 1 | 237 | 385 | 61 | 622 | 10.20 | 622.0 |
| 7 | Western Michigan | 2 | 410 | 631 | 118 | 1041 | 8.82 | 520.5 |