2021 Mid-American Conference Leaders Total Defense - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Miami (Ohio) | 1 | 175 | 112 | 63 | 287 | 4.56 | 287.0 |
| 2 | Eastern Michigan | 1 | 352 | 166 | 75 | 518 | 6.91 | 518.0 |
| 3 | Ohio | 2 | 656 | 188 | 133 | 844 | 6.35 | 422.0 |
| 4 | Bowling Green | 2 | 513 | 203 | 145 | 716 | 4.94 | 358.0 |
| 5 | Ball State | 1 | 240 | 253 | 79 | 493 | 6.24 | 493.0 |
| 6 | Buffalo | 1 | 220 | 296 | 61 | 516 | 8.46 | 516.0 |
| 7 | Northern Illinois | 2 | 644 | 391 | 143 | 1035 | 7.24 | 517.5 |
| 8 | Western Michigan | 2 | 410 | 631 | 118 | 1041 | 8.82 | 520.5 |
| 9 | Akron | 2 | 553 | 682 | 120 | 1235 | 10.29 | 617.5 |
| 10 | Central Michigan | 3 | 308 | 884 | 197 | 1192 | 6.05 | 397.3 |
| 11 | Kent State | 3 | 651 | 888 | 220 | 1539 | 7.00 | 513.0 |