2021 Mid-American Conference Leaders Rushing Defense - From Opponent's 40 to Own 40 Yard Line through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Long | 1st | 10+ | 20+ | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Eastern Michigan | 13 | 129 | 524 | 4.06 | 0 | 34 | 37 | 14 | 3 |
| 1 | Ball State | 13 | 140 | 556 | 3.97 | 0 | 48 | 39 | 17 | 3 |
| 3 | Toledo | 13 | 116 | 416 | 3.59 | 1 | 43 | 26 | 19 | 2 |
| 3 | Central Michigan | 13 | 126 | 427 | 3.39 | 1 | 40 | 31 | 13 | 5 |
| 3 | Ohio | 12 | 110 | 610 | 5.55 | 1 | 55 | 31 | 22 | 6 |
| 3 | Bowling Green | 12 | 135 | 697 | 5.16 | 1 | 50 | 41 | 21 | 4 |
| 7 | Miami (Ohio) | 13 | 134 | 467 | 3.49 | 2 | 50 | 27 | 17 | 2 |
| 7 | Akron | 12 | 126 | 862 | 6.84 | 2 | 46 | 53 | 34 | 7 |
| 9 | Western Michigan | 13 | 107 | 516 | 4.82 | 3 | 55 | 40 | 22 | 7 |
| 9 | Buffalo | 12 | 115 | 590 | 5.13 | 3 | 47 | 36 | 21 | 6 |
| 9 | Kent State | 14 | 183 | 910 | 4.97 | 3 | 50 | 48 | 26 | 8 |
| 12 | Northern Illinois | 14 | 141 | 976 | 6.92 | 4 | 60 | 48 | 32 | 10 |
| 1st: First Downs; 10+: Rush attempts of 10 or more yards; 20+: Rush attempts of 20 or more yards | ||||||||||