2021 Big Ten Conference Leaders Opponent First Downs - Games in December/January Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Maryland | 1 | 5 | 7 | 1 | 13 | 13.0 |
| 2 | Wisconsin | 1 | 7 | 6 | 0 | 13 | 13.0 |
| 2 | Minnesota | 1 | 7 | 7 | 1 | 15 | 15.0 |
| 4 | Michigan State | 1 | 8 | 6 | 0 | 14 | 14.0 |
| 5 | Ohio State | 1 | 10 | 11 | 4 | 25 | 25.0 |
| 6 | Rutgers | 1 | 11 | 13 | 4 | 28 | 28.0 |
| 7 | Michigan | 2 | 14 | 19 | 3 | 36 | 18.0 |
| 8 | Purdue | 1 | 16 | 11 | 4 | 31 | 31.0 |
| 9 | Iowa | 2 | 20 | 20 | 5 | 45 | 22.5 |
| 10 | Penn State | 1 | 21 | 3 | 1 | 25 | 25.0 |