2021 Big Ten Conference Leaders Interceptions - Games in August/September Only through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Riley Moss | Iowa | SR | DB | 4 | 2 | 85 | 2 | 0.50 |
| 2 | Ronnie Hickman | Ohio State | SO | SAF | 4 | 2 | 65 | 1 | 0.50 |
| 3 | Chester Kimbrough | Mich St | JR | CB | 3 | 1 | 62 | 0 | 0.33 |
| 4 | Cameron Martinez | Ohio State | FR | SAF | 4 | 1 | 61 | 1 | 0.25 |
| 5 | Max Melton | Rutgers | FR | DB | 3 | 2 | 46 | 1 | 0.67 |
| 6 | Matt Hankins | Iowa | SR | DB | 4 | 2 | 41 | 0 | 0.50 |
| 6 | Jaquan Brisker | Penn State | SR | S | 4 | 1 | 41 | 0 | 0.25 |
| 8 | Gemon Green | Michigan | SR | DB | 4 | 1 | 27 | 0 | 0.25 |
| 9 | Brandon Joseph | N'western | SO | SAF | 4 | 1 | 26 | 0 | 0.25 |
| 10 | Cody Simon | Ohio State | SO | LB | 4 | 1 | 24 | 0 | 0.25 |
| 11 | Terell Smith | Minnesota | SR | DB | 4 | 1 | 23 | 0 | 0.25 |
| 12 | Luke Reimer | Nebraska | SO | ILB | 5 | 1 | 22 | 0 | 0.20 |
| 13 | Ji'Ayir Brown | Penn State | SR | S | 4 | 2 | 21 | 0 | 0.50 |
| 13 | Tre Avery | Rutgers | SR | DB | 4 | 1 | 21 | 0 | 0.25 |
| 15 | Tyler Nubin | Minnesota | JR | DB | 4 | 1 | 18 | 0 | 0.25 |
| 16 | Jesse Luketa | Penn State | SR | DE | 4 | 1 | 16 | 1 | 0.25 |
| 17 | Deontai Williams | Nebraska | SR | S | 5 | 2 | 11 | 0 | 0.40 |
| 18 | Nick Cross | Maryland | JR | DB | 4 | 2 | 10 | 0 | 0.50 |
| 18 | Mariano Sori-Marin | Minnesota | SR | LB | 4 | 1 | 10 | 0 | 0.25 |
| 20 | Cam Allen | Purdue | JR | S | 4 | 1 | 9 | 0 | 0.25 |
| 21 | Donte Burton | Wisconsin | JR | CB | 2 | 1 | 6 | 0 | 0.50 |
| 21 | Seth Benson | Iowa | JR | LB | 4 | 1 | 6 | 0 | 0.25 |