2021 Big Ten Conference Leaders Interceptions - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Cal Haladay | Mich St | FR | LB | 4 | 1 | 78 | 1 | 0.25 |
| 2 | Ronnie Hickman | Ohio State | SO | SAF | 4 | 2 | 65 | 1 | 0.50 |
| 3 | Cameron Martinez | Ohio State | FR | SAF | 4 | 1 | 61 | 1 | 0.25 |
| 4 | Max Melton | Rutgers | FR | DB | 4 | 2 | 46 | 1 | 0.50 |
| 5 | Matt Hankins | Iowa | SR | DB | 3 | 2 | 41 | 0 | 0.67 |
| 6 | Gemon Green | Michigan | SR | DB | 4 | 1 | 27 | 0 | 0.25 |
| 7 | Brandon Joseph | N'western | SO | SAF | 3 | 1 | 26 | 0 | 0.33 |
| 8 | Cody Simon | Ohio State | SO | LB | 3 | 1 | 24 | 0 | 0.33 |
| 9 | Luke Reimer | Nebraska | SO | ILB | 3 | 1 | 22 | 0 | 0.33 |
| 10 | Tre Avery | Rutgers | SR | DB | 3 | 1 | 21 | 0 | 0.33 |
| 11 | Tyler Nubin | Minnesota | JR | DB | 4 | 1 | 18 | 0 | 0.25 |
| 12 | Jesse Luketa | Penn State | SR | DE | 4 | 1 | 16 | 1 | 0.25 |
| 13 | Ji'Ayir Brown | Penn State | SR | S | 4 | 3 | 15 | 0 | 0.75 |
| 14 | Deontai Williams | Nebraska | SR | S | 3 | 2 | 11 | 0 | 0.67 |
| 15 | Mariano Sori-Marin | Minnesota | SR | LB | 4 | 1 | 10 | 0 | 0.25 |
| 16 | Cam Allen | Purdue | JR | S | 4 | 1 | 9 | 0 | 0.25 |
| 17 | Donte Burton | Wisconsin | JR | CB | 1 | 1 | 6 | 0 | 1.00 |
| 17 | Seth Benson | Iowa | JR | LB | 4 | 1 | 6 | 0 | 0.25 |
| 19 | Nick Cross | Maryland | JR | DB | 4 | 1 | 5 | 0 | 0.25 |
| 20 | Keith Randolph Jr. | Illinois | FR | DL | 2 | 1 | 2 | 0 | 0.50 |