2021 Big Ten Conference Leaders Interceptions - Games Lost Only through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Nick Cross | Maryland | JR | DB | 6 | 1 | 45 | 0 | 0.17 |
| 2 | Scott Nelson | Wisconsin | SR | S | 4 | 1 | 25 | 1 | 0.25 |
| 3 | Terell Smith | Minnesota | SR | DB | 3 | 1 | 23 | 0 | 0.33 |
| 3 | Raheem Layne | Indiana | SR | DB | 10 | 1 | 23 | 0 | 0.10 |
| 5 | Deontai Williams | Nebraska | SR | S | 5 | 2 | 20 | 0 | 0.40 |
| 5 | Bryson Shaw | Ohio State | SO | SAF | 2 | 1 | 20 | 0 | 0.50 |
| 7 | Devon Matthews | Indiana | SR | DB | 8 | 1 | 19 | 0 | 0.13 |
| 8 | Daequan Hardy | Penn State | SO | CB | 6 | 1 | 17 | 1 | 0.17 |
| 9 | Avery Young | Rutgers | JR | DB | 7 | 1 | 16 | 0 | 0.14 |
| 10 | Myles Farmer | Nebraska | FR | S | 9 | 1 | 14 | 0 | 0.11 |
| 11 | Justin White | Mich St | SO | CB | 2 | 1 | 10 | 0 | 0.50 |
| 11 | Mariano Sori-Marin | Minnesota | SR | LB | 4 | 1 | 10 | 0 | 0.25 |
| 13 | Mike Morris | Michigan | JR | DE | 2 | 1 | 5 | 0 | 0.50 |
| 14 | Troy Hudetz | N'western | SR | LB | 9 | 1 | 3 | 0 | 0.11 |
| 15 | Alexander Smith | Wisconsin | JR | CB | 4 | 1 | 2 | 0 | 0.25 |
| 15 | Curtis Jacobs | Penn State | SO | LB | 6 | 1 | 2 | 0 | 0.17 |
| 17 | Jack Campbell | Iowa | JR | LB | 4 | 1 | 1 | 0 | 0.25 |