2021 Big Ten Conference Leaders Long All Purpose Plays - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
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| Name | Team | Yr | Pos | G | Yards | Yards | Yards | Yards | Yards | Yards | Yards | |
| 1 | Jayden Reed | Mich St | JR | WR | 10 | 13 | 7 | 4 | 4 | 3 | 2 | 0 |
| 2 | Braelon Allen | Wisconsin | FR | RB | 10 | 9 | 4 | 3 | 2 | 2 | 0 | 0 |
| 2 | Charlie Jones | Iowa | SR | WR | 12 | 10 | 4 | 2 | 2 | 2 | 1 | 1 |
| 2 | Adrian Martinez | Nebraska | JR | QB | 7 | 2 | 2 | 2 | 2 | 2 | 0 | 0 |
| 2 | Broc Thompson | Purdue | JR | WR | 9 | 3 | 2 | 2 | 2 | 2 | 0 | 0 |
| 2 | Kenneth Walker III | Mich St | JR | RB | 10 | 7 | 3 | 3 | 2 | 2 | 1 | 1 |
| 7 | AJ Barner | Indiana | SO | TE | 7 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 7 | Ronnie Bell | Michigan | SR | WR | 1 | 2 | 1 | 1 | 1 | 1 | 0 | 0 |
| 7 | Zavier Betts | Nebraska | FR | WR | 7 | 3 | 1 | 1 | 1 | 1 | 1 | 0 |
| 7 | Stephan Bracey | Wisconsin | SO | WR | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 7 | Chase Brown | Illinois | SO | RB | 9 | 4 | 1 | 1 | 1 | 1 | 1 | 0 |
| 7 | Ji'Ayir Brown | Penn State | SR | S | 8 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 7 | Blake Corum | Michigan | SO | RB | 8 | 4 | 3 | 3 | 2 | 1 | 0 | 0 |
| 7 | Danny Davis III | Wisconsin | SR | WR | 9 | 2 | 1 | 1 | 1 | 1 | 0 | 0 |
| 7 | Jahan Dotson | Penn State | SR | WR | 8 | 10 | 5 | 2 | 1 | 1 | 1 | 0 |
| 7 | Donovan Edwards | Michigan | FR | RB | 9 | 2 | 2 | 2 | 1 | 1 | 0 | 0 |
| 7 | Emeka Egbuka | Ohio State | FR | WR | 9 | 7 | 4 | 2 | 2 | 1 | 1 | 0 |
| 7 | Isaac Guerendo | Wisconsin | JR | RB | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 7 | TreVeyon Henderson | Ohio State | FR | RB | 9 | 10 | 7 | 5 | 2 | 1 | 0 | 0 |
| 7 | A.J. Henning | Michigan | SO | WR | 10 | 2 | 1 | 1 | 1 | 1 | 0 | 0 |
| 7 | Jacolby Hewitt | Indiana | JR | WR | 5 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 7 | Evan Hull | N'western | SO | RB | 9 | 3 | 1 | 1 | 1 | 1 | 1 | 1 |
| 7 | Cornelius Johnson | Michigan | JR | WR | 10 | 4 | 2 | 2 | 1 | 1 | 1 | 0 |
| 7 | Darryl Jones | Maryland | SR | WR | 9 | 2 | 1 | 1 | 1 | 1 | 0 | 0 |
| 7 | KeAndre Lambert-Smith | Penn State | SO | WR | 8 | 4 | 3 | 2 | 1 | 1 | 1 | 0 |
| 7 | D.J. Matthews Jr. | Indiana | SR | WR | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 7 | Jaxon Smith-Njigba | Ohio State | SO | WR | 9 | 7 | 4 | 2 | 1 | 1 | 0 | 0 |
| 7 | Tarheeb Still | Maryland | SO | DB | 9 | 2 | 2 | 1 | 1 | 1 | 1 | 1 |
| 7 | Samori Toure | Nebraska | SR | WR | 7 | 8 | 4 | 3 | 3 | 1 | 0 | 0 |
| 7 | Miyan Williams | Ohio State | FR | RB | 6 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 7 | Craig Young | Ohio State | SO | SAF | 9 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |