2021 Big Ten Conference Leaders Long All Purpose Plays - Games vs. FBS Teams With Winning Record Only through 01/10/2022
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| Name | Team | Yr | Pos | G | Yards | Yards | Yards | Yards | Yards | Yards | Yards | |
| 1 | TreVeyon Henderson | Ohio State | FR | RB | 9 | 8 | 6 | 5 | 2 | 1 | 0 | 0 |
| 2 | Blake Corum | Michigan | SO | RB | 7 | 5 | 4 | 4 | 2 | 1 | 0 | 0 |
| 2 | Jaxon Smith-Njigba | Ohio State | SO | WR | 9 | 9 | 7 | 4 | 0 | 0 | 0 | 0 |
| 4 | David Bell | Purdue | JR | WR | 7 | 9 | 6 | 3 | 1 | 0 | 0 | 0 |
| 4 | Garrett Wilson | Ohio State | JR | WR | 8 | 3 | 3 | 3 | 1 | 1 | 0 | 0 |
| 6 | Daylen Baldwin | Michigan | SR | WR | 9 | 2 | 2 | 2 | 1 | 0 | 0 | 0 |
| 6 | Michael Brown-Stephens | Minnesota | SO | WR | 6 | 3 | 2 | 2 | 0 | 0 | 0 | 0 |
| 6 | Payne Durham | Purdue | JR | TE | 7 | 2 | 2 | 2 | 1 | 0 | 0 | 0 |
| 6 | Donovan Edwards | Michigan | FR | RB | 8 | 3 | 3 | 2 | 1 | 1 | 0 | 0 |
| 6 | Broc Thompson | Purdue | JR | WR | 8 | 3 | 2 | 2 | 2 | 2 | 0 | 0 |
| 6 | Samori Toure | Nebraska | SR | WR | 8 | 4 | 3 | 2 | 1 | 1 | 0 | 0 |
| 12 | Braelon Allen | Wisconsin | FR | RB | 8 | 3 | 2 | 1 | 1 | 1 | 0 | 0 |
| 12 | Andrel Anthony | Michigan | FR | WR | 9 | 2 | 1 | 1 | 1 | 1 | 1 | 1 |
| 12 | Chris Autman-Bell | Minnesota | SR | WR | 4 | 2 | 1 | 1 | 1 | 0 | 0 | 0 |
| 12 | Ronnie Bell | Michigan | SR | WR | 1 | 2 | 1 | 1 | 1 | 1 | 0 | 0 |
| 12 | Zavier Betts | Nebraska | FR | WR | 8 | 2 | 1 | 1 | 0 | 0 | 0 | 0 |
| 12 | Ji'Ayir Brown | Penn State | SR | S | 7 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 12 | Jerron Cage | Ohio State | SR | DT | 8 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| 12 | Stephen Carr | Indiana | SR | RB | 8 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 12 | Aron Cruickshank | Rutgers | JR | WR | 4 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 12 | Jahan Dotson | Penn State | SR | WR | 6 | 6 | 4 | 1 | 1 | 1 | 1 | 0 |
| 12 | Emeka Egbuka | Ohio State | FR | WR | 7 | 8 | 2 | 1 | 1 | 0 | 0 | 0 |
| 12 | Montorie Foster | Mich St | SO | WR | 8 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| 12 | Ty Fryfogle | Indiana | SR | WR | 10 | 4 | 1 | 1 | 0 | 0 | 0 | 0 |
| 12 | Tyler Goodson | Iowa | JR | RB | 7 | 2 | 1 | 1 | 1 | 0 | 0 | 0 |
| 12 | Isaac Guerendo | Wisconsin | JR | RB | 4 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 12 | Cal Haladay | Mich St | FR | LB | 8 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 12 | A.J. Henning | Michigan | SO | WR | 9 | 2 | 1 | 1 | 1 | 1 | 0 | 0 |
| 12 | Evan Hull | N'western | SO | RB | 6 | 5 | 2 | 1 | 1 | 1 | 0 | 0 |
| 12 | Mohamed Ibrahim | Minnesota | SR | RB | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| 12 | Cornelius Johnson | Michigan | JR | WR | 9 | 3 | 1 | 1 | 1 | 1 | 1 | 0 |
| 12 | Charlie Jones | Iowa | SR | WR | 8 | 7 | 3 | 1 | 1 | 1 | 0 | 0 |
| 12 | George Karlaftis | Purdue | JR | DE | 7 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| 12 | Ivory Kelly-Martin | Iowa | SR | RB | 7 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 12 | KeAndre Lambert-Smith | Penn State | SO | WR | 7 | 5 | 2 | 1 | 0 | 0 | 0 | 0 |
| 12 | Cameron Martinez | Ohio State | FR | SAF | 8 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 12 | Chez Mellusi | Wisconsin | JR | RB | 7 | 3 | 1 | 1 | 1 | 0 | 0 | 0 |
| 12 | Bo Melton | Rutgers | SR | WR | 5 | 4 | 1 | 1 | 0 | 0 | 0 | 0 |
| 12 | Tre Mosley | Mich St | SO | WR | 8 | 2 | 2 | 1 | 0 | 0 | 0 | 0 |
| 12 | Jalen Nailor | Mich St | JR | WR | 4 | 4 | 3 | 1 | 0 | 0 | 0 | 0 |
| 12 | Chris Olave | Ohio State | SR | WR | 8 | 8 | 3 | 1 | 1 | 0 | 0 | 0 |
| 12 | Jayden Reed | Mich St | JR | WR | 8 | 6 | 3 | 1 | 1 | 1 | 1 | 0 |
| 12 | Kenneth Walker III | Mich St | JR | RB | 7 | 4 | 1 | 1 | 0 | 0 | 0 | 0 |
| 12 | Miyan Williams | Ohio State | FR | RB | 7 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 12 | Roman Wilson | Michigan | SO | WR | 9 | 5 | 3 | 1 | 1 | 1 | 0 | 0 |
| 12 | Craig Young | Ohio State | SO | SAF | 8 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |