2021 American Athletic Conference Leaders Tackles For Loss - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | TFL | TFL Yards | TFL/G | |
|---|---|---|---|---|---|
| 1 | Cincinnati | 11 | 81.0 | 334 | 7.36 |
| 2 | Houston | 11 | 77.0 | 325 | 7.00 |
| 3 | UCF | 10 | 76.0 | 335 | 7.60 |
| 4 | Tulane | 9 | 64.0 | 244 | 7.11 |
| 5 | Navy | 12 | 62.0 | 214 | 5.17 |
| 6 | Memphis | 10 | 60.0 | 249 | 6.00 |
| 7 | SMU | 10 | 55.0 | 203 | 5.50 |
| 7 | Temple | 9 | 55.0 | 201 | 6.11 |
| 9 | East Carolina | 10 | 53.0 | 199 | 5.30 |
| 10 | Tulsa | 10 | 52.0 | 162 | 5.20 |
| 11 | South Florida | 9 | 39.0 | 121 | 4.33 |